Schedule for: 19w5128 - The Role of Genomics and Metagenomics in Human Health: Recent Developments in Statistical and Computational Methods

Arriving in Banff, Alberta on Sunday, February 3 and departing Friday February 8, 2019
Sunday, February 3
16:00 - 17:30 Check-in begins at 16:00 on Sunday and is open 24 hours (Front Desk - Professional Development Centre)
17:30 - 19:30 Dinner
A buffet dinner is served daily between 5:30pm and 7:30pm in the Vistas Dining Room, the top floor of the Sally Borden Building.
(Vistas Dining Room)
20:00 - 22:00 Informal gathering (Corbett Hall Lounge (CH 2110))
Monday, February 4
07:00 - 08:45 Breakfast
Breakfast is served daily between 7 and 9am in the Vistas Dining Room, the top floor of the Sally Borden Building.
(Vistas Dining Room)
08:45 - 09:00 Introduction and Welcome by BIRS Staff
A brief introduction to BIRS with important logistical information, technology instruction, and opportunity for participants to ask questions.
(TCPL 201)
09:00 - 09:30 Ryan Hernandez: Human evolutionary history has shaped the genetic architecture of complex trait. (TCPL 201)
09:30 - 10:00 Kirk Lohmueller: Inference of the mutational target size supports the omnigenic model for complex traits. (TCPL 201)
10:00 - 10:30 Iain Mathieson: Performance of polygenic risk scores in diverse populations. (TCPL 201)
10:30 - 11:00 Coffee Break (TCPL Foyer)
11:00 - 11:30 Julia Fukuyama: Unboxing a black box: Properties of phylogenetically-informed distances for microbiome data. (TCPL 201)
11:30 - 13:00 Lunch
Lunch is served daily between 11:30am and 1:30pm in the Vistas Dining Room, the top floor of the Sally Borden Building.
(Vistas Dining Room)
11:30 - 12:00 ZhengZheng Tang: Zero-Inflated Generalized Dirichlet Multinomial (ZIGDM) Regression Model for Microbiome Compositional Data. (TCPL 201)
12:00 - 12:30 Christian Mueller: It’s just a matter of perspective - tuning-insensitive and robust sparse regression for microbiome data. (TCPL 201)
13:00 - 13:45 Guided Tour of The Banff Centre
Meet in the Corbett Hall Lounge for a guided tour of The Banff Centre campus.
(Corbett Hall Lounge (CH 2110))
13:45 - 14:00 Group Photo
Meet in foyer of TCPL to participate in the BIRS group photo. The photograph will be taken outdoors, so dress appropriately for the weather. Please don't be late, or you might not be in the official group photo!
(TCPL 201)
14:00 - 14:30 Hugues Aschard: Balancing complexity in inferring genetic network of multifactorial diseases. (TCPL 201)
14:30 - 15:00 Hae Kyung Im: Current and future method development opportunities to understand the biology of complex traits. (TCPL 201)
15:00 - 15:30 Celia Greenwood: Smooth modeling of covariate effects in bisulfite sequencing-derived measures of DNA methylation. (TCPL 201)
15:30 - 16:00 Coffee Break (TCPL Foyer)
16:00 - 16:30 Xihong Lin: Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole Genome Sequencing Studies. (TCPL 201)
16:30 - 17:00 Shelley Bull: Regression testing for region-based genetic association under genomic partitioning adapted to linkage disequilibrium. (TCPL 201)
17:00 - 17:30 Michael Hoffman: Virtual ChIP-seq: predicting transcription factor binding by learning from the transcriptome. (TCPL 201)
17:30 - 19:30 Dinner
A buffet dinner is served daily between 5:30pm and 7:30pm in the Vistas Dining Room, the top floor of the Sally Borden Building.
(Vistas Dining Room)
Tuesday, February 5
07:00 - 09:00 Breakfast (Vistas Dining Room)
09:00 - 09:30 Ma Jing: Improved Variance Component Score Tests of Marker-Environment Interactions. (TCPL 201)
09:30 - 10:00 Kristin Wallace: Racial differences in microbial and immune infiltrate in colorectal cancers. (TCPL 201)
10:00 - 10:30 Jianxin Shi: Estimating the overall contribution of human oral microbiome to the risk of developing cancers based on prospective studies. (TCPL 201)
10:30 - 11:00 Coffee Break (TCPL Foyer)
11:00 - 11:30 Richard Bonneau: Robust estimation and alignment of mixed spatial and single-cell transcriptomic studies, with application to ALS. (TCPL 201)
11:30 - 13:30 Lunch (Vistas Dining Room)
11:30 - 12:00 Mingyao Li: Deep learning enables accurate clustering and batch effect removal in single-cell RNA-seq analysis. (TCPL 201)
12:00 - 12:30 Kathryn Roeder: Learning from the Transcriptome: analysis of single cell and bulk RNA sequence data. (TCPL 201)
12:30 - 14:00 Lunch (TCPL 201)
14:00 - 14:30 Emilia Huerta-Sanchez: Archaic introgression in admixed individuals. (TCPL 201)
14:30 - 15:00 Itsik Pe'er: Inference of population structure from time-series genotype data. (TCPL 201)
15:00 - 15:30 Coffee Break (TCPL Foyer)
15:30 - 16:00 Nilanjan Chaterjee: Leveraging Polygenic Architecture of Complex Traits to Inform Biology, Causality and Prediction. (TCPL 201)
16:00 - 16:30 Xiaoquan Wen: Bayesian TWAS: a causal inference approach. (TCPL 201)
16:30 - 17:00 Xin He: Accounting for confounding in Mendelian randomization analyses of summary statistics from genome-wide association studies. (TCPL 201)
17:00 - 17:30 Xiang Zhou: Controlling and Testing Horizontal Pleiotropic Effect with the Probabilistic Two- Sample Mendelian Randomization for Transcriptome Wide Association Studies. (TCPL 201)
17:30 - 19:30 Dinner (Vistas Dining Room)
Wednesday, February 6
07:00 - 09:00 Breakfast (Vistas Dining Room)
09:00 - 09:30 James Zou: Machine learning model of CRISPR on-target outcomes reveals new DNA damages. (TCPL 201)
09:30 - 10:00 Ekta Khurana: Prediction of the impact of mutations on chromatin conformation using deep learning. (TCPL 201)
10:00 - 10:30 Coffee Break (TCPL Foyer)
11:30 - 13:30 Lunch (Vistas Dining Room)
13:30 - 17:30 Free Afternoon (Banff National Park)
17:30 - 19:30 Dinner (Vistas Dining Room)
Thursday, February 7
07:00 - 09:00 Breakfast (Vistas Dining Room)
09:00 - 09:30 Brenna Henn: A Rapid, Accurate Approach to Inferring Pedigrees in Endogamous Populations. (TCPL 201)
09:30 - 10:00 Luis Barreiro: Pathogen exposure and pathogen type moderate social status effects on gene regulation in adulthood (TCPL 201)
10:00 - 10:30 Lluis Quintana-Murci: Evolutionary genetic dissection of the genus Homo and its immune response (TCPL 201)
10:30 - 11:00 Coffee Break (TCPL Foyer)
11:00 - 11:30 Michael Epstein: Flexible Strategies for Identifying Factors Involved in Genetic or Metabolic Dysregulation. (TCPL 201)
11:30 - 13:30 Lunch (Vistas Dining Room)
11:30 - 12:00 Ying Wei: Quantile Regression in the Post GWAS Secondary Phenotype Analysis. (TCPL 201)
12:00 - 12:30 Andrew Allen: Improved Pathogenic Variant Localization using a Hierarchical Model of Sub-regional Intolerance. (TCPL 201)
12:30 - 14:00 Lunch (TCPL 201)
14:00 - 14:30 Lisa Strug: Robust Adjusted Profile Likelihood Ratios for the Analysis of Differential Gene Expression (TCPL 201)
14:30 - 15:00 Laura Scott: Determinants of differential gene expression in skeletal muscle and in adipose tissue. (TCPL 201)
15:00 - 15:30 Coffee Break (TCPL Foyer)
15:30 - 16:00 Michael Sohn: Compositional Mediation Model for Binary Outcome. (TCPL 201)
16:00 - 16:30 Zhigang Li: Mediation analysis for zero-inflated mediators. (TCPL 201)
16:30 - 17:00 Lei Liu: Testing mediation effect in high-dimensional compositional microbiome data. (TCPL 201)
17:00 - 17:30 Huilin Li: A powerful two-stage microbiome-wide association test. (TCPL 201)
17:30 - 19:30 Dinner (Vistas Dining Room)
Friday, February 8
07:00 - 09:00 Breakfast (Vistas Dining Room)
09:00 - 12:00 Group discussions (TCPL 201)
10:00 - 10:30 Coffee Break (TCPL Foyer)
11:30 - 12:00 Checkout by Noon
5-day workshop participants are welcome to use BIRS facilities (BIRS Coffee Lounge, TCPL and Reading Room) until 3 pm on Friday, although participants are still required to checkout of the guest rooms by 12 noon.
(Front Desk - Professional Development Centre)
12:00 - 13:30 Lunch from 11:30 to 13:30 (Vistas Dining Room)