Schedule for: 18w5154 - New Statistical Methods for Family-Based Sequencing Studies

Arriving in Banff, Alberta on Sunday, August 5 and departing Friday August 10, 2018
Sunday, August 5
16:00 - 17:30 Check-in begins at 16:00 on Sunday and is open 24 hours (Front Desk - Professional Development Centre)
17:30 - 19:30 Dinner
A buffet dinner is served daily between 5:30pm and 7:30pm in the Vistas Dining Room, the top floor of the Sally Borden Building.
(Vistas Dining Room)
20:00 - 22:00 Informal gathering (Corbett Hall Lounge (CH 2110))
Monday, August 6
07:00 - 08:45 Breakfast
Breakfast is served daily between 7 and 9am in the Vistas Dining Room, the top floor of the Sally Borden Building.
(Vistas Dining Room)
08:45 - 09:00 Introduction and Welcome by BIRS Staff
A brief introduction to BIRS with important logistical information, technology instruction, and opportunity for participants to ask questions.
(TCPL 201)
09:00 - 10:00 1 - Methodological Aspects of Familial Analyses
Speakers: Ellen Wijsman (University of Washington), Karim Oualkacha (Université du Québec à Montréal)
(TCPL 201)
09:00 - 09:30 Ellen Wijsman: Correcting for confounding introduced by batch effects and imputation in family-based designs with whole genome sequence data (TCPL 201)
09:30 - 10:00 Karim Oualkacha: A General Framework for Variable Selection in Linear Mixed Models with Applications to Genetic Studies with Structured Populations (TCPL 201)
10:00 - 10:30 Coffee Break (TCPL Foyer)
10:29 - 11:45 1 - Methodological Aspects of Familial Analyses (continued)
Speakers: Tim Thornton (University of Washington), Ingo Ruczinski (Johns Hopkins University), Christina Nieuwoudt (Simon Fraser University)
(TCPL 201)
10:30 - 10:55 Timothy Thornton: Challenges and new approaches for whole genome analysis in multi-ethnic studies with pedigrees (TCPL 201)
10:55 - 11:20 Ingo Ruczinski: Sharing of rare nucleotide and copy number variants in extended multiplex families (TCPL 201)
11:20 - 11:45 Christina Nieuwoudt: Simulating family studies with whole-exome sequencing of multiple affected relatives (TCPL 201)
11:45 - 13:00 Lunch
Lunch is served daily between 11:30am and 1:30pm in the Vistas Dining Room, the top floor of the Sally Borden Building.
(Vistas Dining Room)
13:00 - 14:00 Small group meetings (Around BIRS)
14:00 - 14:15 Group Photo
Meet in foyer of TCPL to participate in the BIRS group photo. The photograph will be taken outdoors, so dress appropriately for the weather. Please don't be late, or you might not be in the official group photo!
(TCPL 201)
14:14 - 15:00 2 - Genealogies and Founder Populations
Speakers: Simon Gravel (McGill University), Arthur Gilly (Sanger Institute)
(TCPL 201)
14:15 - 14:45 Simon Gravel: Inferring allele transmissions in very large genealogies (TCPL 201)
14:45 - 15:00 Arthur Gilly: Next-generation sequencing studies in founder populations (TCPL 201)
15:00 - 15:30 Coffee Break (TCPL Foyer)
15:29 - 16:00 2- Genealogies and Founder Populations
Speaker: Alexandre Bureau
(TCPL 201)
15:30 - 16:00 Alexandre Bureau: Rare variant sharing methods with genealogies (TCPL 201)
16:00 - 18:00 Poster Session (TCPL foyer)
18:00 - 19:30 Dinner
A buffet dinner is served daily between 5:30pm and 7:30pm in the Vistas Dining Room, the top floor of the Sally Borden Building.
(Vistas Dining Room)
Tuesday, August 7
07:00 - 09:00 Breakfast (Vistas Dining Room)
08:59 - 10:00 3- Priorizing rare variants / fine mapping
Speakers: Shelley Bull (University of Toronto), Iuliana Ionita-Laza (Columbia University)
(TCPL 201)
09:00 - 09:30 Shelley Bull: Whole exome sequencing of affected sister pairs with early onset breast cancer (TCPL 201)
09:30 - 10:00 Iuliana Ionita-Laza: Statistical methods for the integration of functional genomics data and whole exome/genome sequencing data for improved gene discovery (TCPL 201)
10:00 - 10:30 Coffee Break (TCPL Foyer)
10:30 - 11:15 3- Priorizing rare variants / fine mapping (continued)
Speakers: Heather Cordell (Newcastle University), Lai Jiang (McGill University)
(TCPL 201)
10:30 - 10:45 Heather Cordell: Lessons learned from sequencing under a linkage peak in families with vesicoureteric reflux (TCPL 201)
10:45 - 11:15 Lai Jiang: Estimating the effects of copy number variants on intelligence quotient using hierarchical Bayesian models (TCPL 201)
11:15 - 12:00 Small group meetings (TCPL 201)
12:00 - 13:30 Lunch (Vistas Dining Room)
13:30 - 15:00 4 - Combining Familial and Population-based Designs
Speakers: Laura Almasy (University of Texas Health Science Center), Simon Girard (Université du Québec à Chicoutimi), JC Loredo-Osti (Memorial University)
(TCPL 201)
13:30 - 14:00 Laura Almasy: What's under those old linkage peaks? Combining family and cohort analyses to overcome the limitations of large shared segments (TCPL 201)
14:00 - 14:30 Simon Girard: Using populations and pedigrees structures to identify genetic variations associated with epilepsy (TCPL 201)
14:30 - 15:00 J-C Loredo-Osti: Joint modelling of family and case controls through mixtures (TCPL 201)
15:00 - 15:30 Coffee Break (TCPL Foyer)
15:29 - 17:30 5 - Population Genetics and Structure
Speakers: Jinko Graham (Simon Fraser University), Kelly Burkett (University of Ottawa), Elizabeth Thompson (University of Washington), Bhagya Charith Karunarathna (Simon Fraser University), Renaud Alie (Université du Québec à Montréal)
(TCPL 201)
15:30 - 16:00 Jinko Graham: Combining phenotypes, genotypes and gene genealogies to find trait-influencing variants (TCPL 201)
16:00 - 16:30 Elizabeth Thompson: Inferences from identity by descent in related individuals: pedigree relationships in conjunction and in contrast (TCPL 201)
16:30 - 16:45 Charith Bhagya Karunarathna: Using gene genealogies to localize trait-influencing variants in diploid populations (TCPL 201)
16:45 - 17:00 Renaud Alie: Construction of coalescent trees on partially fixed pedigrees (TCPL 201)
18:00 - 20:00 Dinner (Vistas Dining Room)
Wednesday, August 8
07:00 - 09:00 Breakfast (Vistas Dining Room)
09:00 - 10:00 6- Region-based and Multiple Variant Familial Association Methods
Speakers : Holger Schwender (University of Dusseldorf), Julian Hecker (Harvard University)
(TCPL 201)
09:00 - 09:30 Kelly Burkett: Sampling gene genealogies conditional on genotype data from trios (TCPL 201)
09:30 - 10:00 Julian Hecker: A general framework for the region-based analysis of rare variants data in family-based association studies (TCPL 201)
10:00 - 10:30 Coffee Break (TCPL Foyer)
10:30 - 11:30 6- Region-based and Multiple Variant Familial Association Methods
Speakers: Laurent Briollais (University of Toronto), Dandi Qiao (Harvard University), Mariza de Andrade (Mayo Clinic)
(TCPL 201)
10:30 - 11:00 Laurent Briollais: A novel Bayesian region-based analysis for next generation sequencing data (TCPL 201)
11:00 - 11:30 Dandi Qiao: Gene-based segregation method for identifying rare variants in family-based sequencing studies (TCPL 201)
11:30 - 12:00 Mariza de Andrade: Insights from whole genome sequencing of a family with Venous Thromboembolism (TCPL 201)
12:00 - 13:00 Lunch (Vistas Dining Room)
13:00 - 18:00 Hiking / Free Afternoon (Banff National Park)
18:00 - 20:00 Dinner (Vistas Dining Room)
Thursday, August 9
07:00 - 09:00 Breakfast (Vistas Dining Room)
09:00 - 10:00 7- Time-to-Event and Multivariate Phenotypes
Speakers: Yun-Hee Choi (University of Western Ontario), Jooyoung Lee (University of Waterloo)
(TCPL 201)
09:00 - 09:30 Yun-Hee Choi: Analysis of sequencing data with survival outcomes in family-based study using a correlated frailty model (TCPL 201)
09:30 - 10:00 Jooyoung Lee: Illness-death models for family studies: accounting for competing risks and biased sampling (TCPL 201)
10:00 - 10:30 Coffee Break (TCPL Foyer)
10:30 - 12:00 7 - Time-to-Event and Multivariate Phenotypes (continued)
Speakers: M'Hamed Lajmi Lakhal Chaieb (Université Laval), Yildiz Yilmaz (Memorial University), Xihong Lin (Harvard University)
(TCPL 201)
10:30 - 11:00 Lajmi Lakhal Chaieb: Testing the heritability and parent-of-origin hypotheses for ages at onset of psoriatic arthritis under biased sampling (TCPL 201)
11:00 - 11:30 Yildiz Yilmaz: Copula modeling of dependent traits in rare variant analysis (TCPL 201)
11:30 - 12:00 Xihong Lin: Testing of mediation effects and pleiotropy in genome-wide studies: testing a large number of composite null hypotheses (TCPL 201)
12:00 - 13:30 Lunch (Vistas Dining Room)
13:30 - 15:00 8 - Detecting Genetic Features from Sequence Data
Speakers: Rob Scharpf (Johns Hopkins University), Ken Lange (University of California at Los Angeles), Margaret Taub (Johns Hopkins University)
(TCPL 201)
13:30 - 14:00 Rob Scharpf: Genotyping germline copy number variants in large trio-based studies (TCPL 201)
14:00 - 14:30 Ken Lange: Ultrafast haplotyping (TCPL 201)
14:30 - 15:00 Margaret Taub: Telomere length estimation and analysis from WGS data (TCPL 201)
15:00 - 15:30 Coffee Break (TCPL Foyer)
15:30 - 16:30 8 - Detecting Genetic Features from Sequence Data (continued)
Speakers: Janet Sinsheimer (University of California at Los Angeles), Jack Fu (Johns Hopkins University), Kaiqiong Zhao (Mc Gill University)
(TCPL 201)
15:30 - 16:00 Janet Sinsheimer: Take nothing for granted: Calculating the heritability of the microbiome of a proto-social beetle using NGS data (TCPL 201)
16:00 - 16:15 Jack Fu: De novo copy number deletion detection with read depth (TCPL 201)
16:15 - 16:30 Kaiqiong Zhao: Smooth modeling of covariate effects in bisulfite sequencing-derived measures of DNA methylation (TCPL 201)
17:30 - 19:30 Dinner (Vistas Dining Room)
Friday, August 10
07:00 - 09:00 Breakfast (Vistas Dining Room)
09:00 - 10:00 Discussion session (TCPL 201)
10:00 - 10:30 Coffee Break (TCPL Foyer)
10:30 - 11:30 Discussion session (TCPL 201)
11:30 - 12:00 Checkout by Noon
5-day workshop participants are welcome to use BIRS facilities (BIRS Coffee Lounge, TCPL and Reading Room) until 3 pm on Friday, although participants are still required to checkout of the guest rooms by 12 noon.
(Front Desk - Professional Development Centre)
12:00 - 13:30 Lunch from 11:30 to 13:30 (Vistas Dining Room)